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Apexbio Technology LLC Ciprofloxacin hydrochloride hydrate 86393-32-0 5g

Supplier: Apexbio Technology LLC C65105000
Ciprofloxacin hydrochloride hydrate (CAS 86393-32-0) is a small-molecule inhibitor targeting bacterial DNA topoisomerase IV It is designed to inhibit topoisomerase IV-mediated DNA processes thereby impairing DNA replication and promoting DNA damage Ciprofloxacin hydrochloride hydrate exerts its biological activity primarily through inhibition of bacterial DNA topoisomerase IV leading to disruption of nuclear and mitochondrial DNA integrity mitochondrial dysfunction and increased intracellular reactive oxygen species (ROS) In cellular assays ciprofloxacin hydrochloride hydrate demonstrates inhibitory activity with IC50 values typically ranging between 5 50 M depending on the cell type and experimental conditions Based on these pharmacological properties ciprofloxacin hydrochloride hydrate holds research potential in elucidating fluoroquinolone-induced topoisomerase inhibition apoptotic pathways DNA damage responses and antiproliferative effects
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