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Medchemexpress LLC Cirtuvivint (SM08502) | 2143917-62-6 | 98.1% | 427.50 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY13743550MG

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Cirtuvivint (SM08502) is a potent and orally active CDC-like kinase (CLK) inhibitor used for solid tumors research.

  • Inhibits serine and arginine rich splicing factor (SRSF) phosphorylation
  • Disrupts spliceosome activity
  • Linked to inhibition of Wnt pathway-related gene and protein expression
  • Induces splicing variants of Wnt pathway genes
  • Significantly inhibits growth of gastrointestinal tumors in xenograft mouse models
  • Decreases SRSF phosphorylation and Wnt pathway gene expression in xenograft mouse models
  • Exhibits an IC50 of 0.18 μM for HT-22 cells
  • Shows an EC50 of 17 nM for NCI-N87 cells

Catalog No. 50-003-50704


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