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Apexbio Technology LLC CITCO 338404-52-7 10mg
Supplier: Apexbio Technology LLC B746810
CITCO (CAS 338404-52-7) is an imidazothiazole derivative that selectively activates the human constitutive androstane receptor (CAR) exhibiting an EC50 of 49 nM and over 50-fold selectivity for CAR compared to the pregnane X receptor (PXR) with negligible activity on other nuclear receptors Activation of CAR by CITCO facilitates its nuclear translocation and subsequent binding to response elements regulating gene expression processes involved in hepatic detoxification pathways Additionally CITCO-mediated CAR activation has been shown to suppress the proliferation and expansion of brain tumor stem cells supporting its utility in studies of xenobiotic metabolism and cancer biology
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