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Medchemexpress LLC CJJ300 | 1807631-83-9 | 99.4% | 435.60 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY146693100MG

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CJJ300 is a transforming growth factor-β (TGF-β) inhibitor with an IC50 of 5.3 μM. It inhibits TGF-β signaling by disrupting the formation of the TGF-β-TβR-I-TβR-II signaling complex. It also disturbs protein-protein interactions, prevents TGF-β receptor dimerization, and suppresses the expression of markers of epithelial-mesenchymal transition (EMT) without cytotoxicity. In human A549 lung epithelial cells, it attenuated the increase of P-Smad2/Smad3, P-Erk1/2, and P-Akt induced by TGF-β. It also down-regulated the expression of EMT-associated proteins, including fibronectin, α-SMA, and MMP-2.

Catalog No. 50-003-60914


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