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AdipoGen CK2 Inhibitor 10
SDP

Supplier:  AdipoGen AGCR13626M001

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Chemical. CAS 1361229-76-6. Formula C18H14N2O4S . 0.5H2O. MW 354.4 . 9.0. Potent and ATP-competitive inhibitor of casein kinase 2 IC50 CK2alpha=32nM and IC50 CK2alpha=46nM. Potently also inhibits DYRK1B and FLT3. Anticancer compound. Exhibits potent cytotoxicity towards lung cancer cells A549, colorectal cancer cells HCT-116 and breast cancer cells MCF-7. Promoted cAMP-induced thermogenesis in white adipocytes. CK2 inhibition ameliorates diet-induced obesity and insulin resistance in mice in vivo by promoting UCP1-dependent thermogenesis.

Catalog No. 50-256-2261


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