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Medchemexpress LLC Cklf1-c19 | 960358-79-6 | 99.8% | 2225.54 | 1 MG
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Supplier:  Medchemexpress LLC HYP39821MG

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CKLF1-C19 is the C-terminal peptide of human chemokine-like factor 1 (CKLF1). It interacts with CCR4 and inhibits chemotaxis induced by both CKLF1 and CCL17. CKLF1-C19 has demonstrated the ability to suppress allergic lung inflammation by inhibiting chemotaxis mediated by CCR3 and CCR4.

  • Induces chemotactic migration of human Th2 cells at concentrations of 200 ng/mL or 500 ng/mL for 30 minutes.
  • Inhibits CCL11-induced chemotaxis of mouse eosinophils and human CCR3-transfected or mouse CCR3-transfected HEK293 cells at 100 ng/mL for 30 minutes.
  • A single intraperitoneal dose (0.01-100 μg, 200 μL) administered 30 minutes before OVA induction significantly reduces airway hyperresponsiveness (AHR) in comparison to the ovalbumin (OVA) group treated with saline.
  • A single subcutaneous dose (0.5 mg or 1 mg, 200 μL) decreases CCL11-mediated recruitment of eosinophils into the peritoneal cavity in a mouse model of asthma.

Catalog No. 50-003-99332


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