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Apexbio Technology LLC CL 82198 hydrochloride 307002-71-7 5mg
Supplier: Apexbio Technology LLC A44345
CL 82198 hydrochloride (CAS 307002-71-7) is a selective inhibitor of matrix metalloproteinase-13 (MMP-13) showing negligible activity against related enzymes such as MMP-1 MMP-9 and TACE MMP-13 is involved in extracellular matrix remodeling and its dysregulation contributes to pathological tissue degradation In vitro CL 82198 at 10 g/mL achieves 89% inhibition of MMP-13 activity Structural studies indicate that CL 82198 binds the S1 pocket of MMP-13 underpinning its selectivity In animal models it reduces ibuprofen-induced gastric injury in a dose-dependent manner supporting its utility in studies of MMP-13-related pathologies and gastrointestinal protection mechanisms
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