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Apexbio Technology LLC Cladribine 4291-63-8 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A21875.1
Cladribine (CAS 4291-63-8) is a purine nucleoside analog functioning as an inhibitor of adenosine deaminase an enzyme critical in purine metabolism It demonstrates potent antiproliferative effects on lymphoproliferative diseases notably hairy cell leukemia In multiple myeloma cell lines (U266 RPMI8226 MM1 S) Cladribine inhibits cell proliferation and induces apoptosis in a dose-dependent manner associated with activation of caspase pathways (caspase-3 -8 -9) and PARP cleavage inhibition of STAT3 phosphorylation DNA damage and activation of tumor suppressor p53 Cladribine is widely investigated for oncology research applications due to these molecular mechanisms
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