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Medchemexpress LLC Clodronic acid disodium salt | 22560-50-5 | 100.5% | 50 MG
Supplier: Medchemexpress LLC HYB0657A50MG
Clodronic acid (Clodronate) disodium salt is a first-generation bisphosphonate and an orally active osteoclastic bone resorption inhibitor. It is used in high bone turnover states, Paget's disease, and osteolytic bone metastases. It induces rapid apoptosis in osteoclasts by inhibiting ATP production.
- Induces rapid apoptosis in osteoclasts by inhibiting ATP production, leading to the release of cytochrome C into the cytoplasm.
- Slightly decreases hindpaw swelling in rats with adjuvant arthritis at doses of 12.5 and 25 mg/kg.
- Used in clinical trials for various conditions including breast cancer, hip arthrosis, pain, prostate cancer, osteoarthritis of knee, and postmenopausal osteoporosis.
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