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Medchemexpress LLC CLP257 | 1181081-71-9 | 99.3% | 307.34 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY11014310MG

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CLP257 is a selective K+-Cl cotransporter KCC2 activator with an EC50 of 616 nM. It restores impaired chloride transport in neurons with diminished KCC2 activity and alleviates hypersensitivity in rats with neuropathic pain. This compound also modulates plasmalemmal KCC2 protein turnover post-translationally.

  • Selective K+-Cl cotransporter KCC2 activator
  • Restores impaired chloride transport in neurons
  • Alleviates hypersensitivity in rats with neuropathic pain
  • Modulates plasmalemmal KCC2 protein turnover post-translationally
  • Inactive against NKCC1, GABAA receptors, KCC1, KCC3, or KCC4

Catalog No. 50-003-43731


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