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Medchemexpress LLC CO23 | 1370363-74-8 | 98.0% | 1 MG
SDP

Supplier:  Medchemexpress LLC HY1300121MG

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CO23 is a selective thyroid hormone receptor (TR) α agonist, utilized for its role in growth and development regulation. This product is intended for research use only and is not sold to patients.

  • Selective thyroid hormone receptor (TR) α agonist.
  • Supports growth and development regulation.
  • Exhibits EC50 of 11 nM for human TRalpha transactivation activity in HeLa cells.
  • Shows EC50 of 58 nM for human TRbeta transactivation activity in HeLa cells.
  • Demonstrates EC50 of 34 nM for human TRalpha transactivation activity in U2OS cells.
  • Achieves EC50 of 390 nM for human TRbeta transactivation activity in U2OS cells.
  • Reduces cholesterol by approximately 50% at a 0.8 nmol/g dose in hypothyroid Wistar rats.
  • Increases Dio1 mRNA 5-, 10-, and 15-fold at doses of 0.8, 2.5, and 5 nmol/g in hypothyroid Wistar rats.

Catalog No. 50-003-38515


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