ABclonal Technology Collagen IV Rabbit mAb

Supplier:  ABclonal Technology A2591620UL

Type IV collagen is a key component of basement membranes formed by three alpha subunits encoded by six genes This gene encodes alpha 3 In Goodpasture syndrome autoantibodies target the C-terminal domain and a specific kinase phosphorylates this region during disease Mutations in this gene are associated with autosomal recessive Alport syndrome The protein consists of a 7S domain a triple-helix collagenous domain and a C-terminal non-collagenous domain interacting with extracellular matrix components like perlecans and laminins Cleavage of the C-terminal domain forms arresten an anti-angiogenic fragment Mutations cause porencephaly cerebrovascular disease and renal defects The gene shares a bidirectional promoter with a paralogous gene and alternative splicing produces multiple transcript variants

Catalog No. 50-000-12633