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Apexbio Technology LLC Combretastatin A4 117048-59-6 5mg
Supplier: Apexbio Technology LLC B67645
Combretastatin A4 (CAS 117048-59-6) is a naturally derived stilbene compound that acts as a vascular disrupting agent Its primary mechanism involves binding to the colchicine site on tubulin inhibiting microtubule polymerization and leading to endothelial cell cytoskeletal disruption within tumor vasculature This process results in rapid vascular collapse and subsequent tumor necrosis In research settings Combretastatin A4 is utilized to investigate tumor blood supply targeting and to assess anti-angiogenic therapies Caution is advised when co-administered with agents such as Darbepoetin alfa as the combination can elevate the likelihood or severity of thrombotic events
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