Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC Complement C5-IN-1 | 2365402-67-9 | 99.1% | 1 ML
Supplier: Medchemexpress LLC HY12834210MM/1ML
Complement C5-IN-1 is a selective allosteric inhibitor of complement component protein C5. It prevents C5 from being cleaved by C5 convertase, which inhibits the cleavage of C5 into C5a and C5b, thus blocking the formation of the membrane attack complex (MAC).
- Selective allosteric inhibitor of complement component protein C5
- Prevents C5 from being cleaved by C5 convertase
- Inhibits the cleavage of C5 into C5a and C5b
- Blocks the formation of the membrane attack complex (MAC)
- Exhibits an IC50 of 0.77 μM in 50% human whole blood
- Exhibits an IC50 of 5 nM in 2% human serum to block MAC deposition induced by zymosan
- Useful for studying diseases associated with complement overactivation, such as paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS)
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?