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Medchemexpress LLC Copanlisib | 1032568-63-0 | 480.52 | 100 MG
Supplier: Medchemexpress LLC 100MGHY15346
Copanlisib is a potent, selective, and ATP-competitive pan-class I PI3K inhibitor. It demonstrates over 2,000-fold selectivity against other lipid and protein kinases, with the exception of mTOR, and exhibits superior antitumor activity, making it suitable for cancer research.
- Potent, selective, and ATP-competitive pan-class I PI3K inhibitor
- Has IC₅₀s of 0.5 nM for PI3Kα, 0.7 nM for PI3Kδ, 3.7 nM for PI3Kβ, and 6.4 nM for PI3Kγ
- Exhibits over 2,000-fold selectivity against other lipid and protein kinases (excluding mTOR)
- Demonstrates superior antitumor activity
- Induces apoptosis in a subset of tumor cell lines
- Completely inhibits PI3K-mediated AKT phosphorylation
- Potently inhibits cell proliferation in various human tumor cell lines
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