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Medchemexpress LLC Coptisine chloride | 6020-18-4 | 355.77 | 1 ML
SDP

Supplier:  Medchemexpress LLC HYN073610MM/1ML

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Coptisine chloride is an alkaloid derived from Chinese goldthread. It functions as an efficient uncompetitive inhibitor of IDO (Indoleamine 2,3-dioxygenase), with a Ki value of 5.8 μM and an IC50 value of 6.3 μM. Additionally, Coptisine chloride is a potent inhibitor of H1N1 neuraminidase (NA-1), exhibiting an IC50 of 104.6 μg/mL, making it useful for combating influenza A (H1N1) infection.

  • Efficient uncompetitive IDO inhibitor.
  • Potent H1N1 neuraminidase (NA-1) inhibitor, useful for influenza A (H1N1) infection.
  • Inhibits proliferation of various cancer cell lines.
  • Induces G2/M arrest and apoptosis in A549 cells.
  • Increases ROS levels in A549 cells.
  • Decreases levels of TC, TG, and LDL-c while increasing HDL-c in hamsters.
  • Suppresses HMGCR and induces SREBP-2, LDLR, and CYP7A1 expression.

Catalog No. 50-004-17145


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