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Medchemexpress LLC Cot inhibitor-2 | 915363-56-3 | 99.65% | 539.43 | 5 MG
Supplier: Medchemexpress LLC HY320185MG
Cot inhibitor-2 is a potent, selective, and orally active cot (Tpl2/MAP3K8) inhibitor with an IC50 of 1.6 nM. It inhibits TNF-α production in LPS-stimulated human whole blood with an IC50 of 0.3 μM.
- Potent, selective, and orally active cot (Tpl2/MAP3K8) inhibitor.
- Inhibits TNF-α production.
- Demonstrated Cmax of 517 ng/mL (0.89 μM) and AUC of 4841 ng h/mL in rats with 100 mg/kg dosing.
- Inhibits LPS-induced TNF-α production by 83% at a 25 mg/kg oral dose in Sprague-Dawley rats.
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