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Medchemexpress LLC CP681301 | 865317-32-4 | 99.13% | 298.38 | 500 MG
SDP

Supplier:  Medchemexpress LLC HY150082500MG

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CP681301 is a potent CDK5 inhibitor exhibiting antiproliferative activity. It effectively decreases the expression of CD133, OLIG2, SOX2, KI67, and pCDK5 protein levels in Glioma stem cells (GSCs). This compound also reduces self-renewal in mouse glioma xenografts and shows anti-tumor activity in Drosophila.

  • Potent CDK5 inhibitor
  • Shows antiproliferative activity
  • Decreases expression of CD133, OLIG2, SOX2, KI67, and pCDK5 protein level in GSCs
  • Reduces self-renewal in mouse glioma xenografts
  • Demonstrates anti-tumor activity in Drosophila
  • Variably cytotoxic effects on GSC cultures
  • Not toxic to normal human neuro-progenitors (NHNPs)
  • Suppresses CREB Ser133 phosphorylation expression
  • Increases median survival in Drosophila models

Catalog No. 50-003-61267


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