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Cayman Chemical CPEPS8NLStrIfluoroACTAte 10mg
Supplier: Cayman Chemical 4174310 MG
A cell-penetrating peptide inhibitor of EPS8 nuclear translocation; induces apoptosis and cell cycle arrest in the G0/G1 phase in THP-1, HL-60, and U937 cells at 70 µM; reduces phosphorylated ERK, STAT3, and Akt levels in THP-1, HL-60, and U937 cells at 35 or 70 µM; reduces tumor volume without affecting body weight in a U937 mouse xenograft model at 55 mg/kg every other day; decreases tumor volume alone or in combination with daunorubicin in a KG-1 AML mouse xenograft model at 50 mg/kg every other day
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