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Apexbio Technology LLC CPI-637 1884712-47-3 10mg
Supplier: Apexbio Technology LLC B780110
CPI-637 (CAS 1884712-47-3) is a selective small molecule inhibitor targeting the bromodomains of CBP (CREB-binding protein) and EP300 with IC50 values of 0 03 M and 11 0 M respectively It demonstrates over 700-fold selectivity for CBP/EP300 bromodomains relative to the BET bromodomain family and displays significant selectivity over other bromodomain-containing proteins with notable biochemical activity observed only against BRD9 In cellular assays CPI-637 inhibits MYC expression with an EC50 of 0 60 M and effectively engages CBP in BRET assays (EC50 0 3 M) CPI-637 is currently utilized in preclinical research to investigate the role of CBP/EP300 bromodomains in transcriptional regulation and disease pathways
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