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Medchemexpress LLC Cpi1 | 3085809-95-3 | 99.3% | 2299.43 | 1 MG
Supplier: Medchemexpress LLC HYP108561MG
CPI1 is a multidrug resistance protein 1 (MRP1) inhibitor with a Ki value of 100 nM. It functions by binding to the same substrate-binding site as leukotriene C4, which stabilizes MRP1 in an apo-like inward-facing conformation. This action blocks the necessary conformational changes for ATP hydrolysis and substrate transport, thereby inhibiting the ATPase activity of human and bovine MRP1. CPI1 is a valuable tool for investigating the substrate transport mechanism of MRP1 and is applicable to research concerning cancer multidrug resistance.
- Potent inhibitor of MRP1 with a Ki value of 100 nM.
- Inhibits both basal and leukotriene C4-stimulated ATPase activity of bovine MRP1.
- Serves as a research tool for understanding MRP1 substrate transport.
- Applicable to research concerning cancer multidrug resistance.
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