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Medchemexpress LLC CR-1-31-B | 1352914-52-3 | >98.38% | 507.53 | 25 MG
Supplier: Medchemexpress LLC 25MGHY136453
CR-1-31-B is a synthetic rocaglate and a potent eIF4A inhibitor. It effectively inhibits eIF4A by disrupting the interaction between eIF4A and RNA, thereby impeding protein synthesis initiation. This compound also interferes with the association of Plasmodium falciparum eIF4A (PfeIF4A) with RNA and has been shown to induce apoptosis in neuroblastoma and gallbladder cancer cells.
- Inhibits eIF4A by disrupting RNA interaction
- Impairs protein synthesis initiation
- Interferes with PfeIF4A association with RNA
- Induces apoptosis in neuroblastoma and gallbladder cancer cells
- Inhibits MUC1-C translation
- Decreases MUC1-C abundance
- Sensitizes gallbladder cancer cells to TRAIL-mediated apoptosis
- Increases reverse glutamine metabolism in pancreatic cancer cells
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