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Selleck Chemical LLC Crizotinib hydrochloride S5190-25mg
Supplier: Selleck Chemical LLC S519025MG
Crizotinib (PF-02341066) hydrochloride (Xalkori) inhibits tyrosine phosphorylation of c-Met and nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) with IC50 of of 11 nM and 24 nM in cell-based assays respectively Crizotinib hydrochloride is also a potent ROS1 inhibitor with Ki less than 0 025 nM Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines
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