Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
ABclonal Technology CRYAB Rabbit pAb
Supplier: ABclonal Technology A136961000UL
Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins consist of two gene products, alpha-A (acidic) and alpha-B (basic), and belong to the small heat shock protein (HSP20) family. Induced by heat shock, they act as molecular chaperones by forming large soluble aggregates, rather than renaturing proteins like true chaperones. These aggregates consist of 30-40 subunits, with a 3:1 ratio of alpha-A to alpha-B subunits. Alpha crystallins also have autokinase activity and contribute to intracellular architecture. The encoded protein is a "moonlighting" protein, performing distinct functions. Alpha-A is primarily expressed in the lens, while alpha-B is found in many tissues. Elevated alpha-B expression is linked to neurological diseases, and a missense mutation is associated with desmin-related myopathy. Alternative splicing results in multiple transcript variants.
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?