Medchemexpress LLC CSK-IN-1 | 2380027-49-4 | 98.6% | 50 MG

Supplier:  Medchemexpress LLC HY13025450MG

CSK-IN-1 (compound 13) is a potent, orally active c-terminal Src kinase (CSK) inhibitor with IC50 values below 3 nM and 4 nM in CSK HTRF and Caliper assay, respectively. It increases T cell proliferation induced by T cell receptor signaling. This product is for research use only.

• Potent, orally active c-terminal Src kinase (CSK) inhibitor
• Achieves IC50 values below 3 nM in CSK HTRF assay
• Achieves IC50 values below 4 nM in Caliper assay
• Increases T cell proliferation induced by T cell receptor signaling
• Reduces inhibitory LCK phosphorylation in vivo upon oral dosing
• Enhances T cell activation in response to antigen stimulation
• Shows EC50 of 41 nM on ZAP70 phosphorylation in human Jurkat cells

Catalog No. 50-003-38858