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Apexbio Technology LLC CTS-1027 193022-04-7 50mg
Supplier: Apexbio Technology LLC A333450
CTS-1027 (CAS 193022-04-7) is a selective inhibitor of matrix metalloproteinases (MMPs) demonstrating high potency against MMP-2 and MMP-13 with IC values of 0 4 nM and 0 6 nM respectively MMPs are zinc-dependent endopeptidases involved in degradation of extracellular matrix proteins modulation of membrane receptors the release of apoptotic ligands and inactivation of chemokines and cytokines These enzymes are implicated in numerous cellular processes including proliferation migration differentiation angiogenesis and apoptosis In a murine model of bile duct ligation oral administration of CTS-1027 reduced hepatic injury and fibrosis supporting its use as a tool for investigating MMP function and fibrotic disease mechanisms
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