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Selleck Chemical LLC CVN293 E4642-1G
Supplier: Selleck Chemical LLC E46421G
CVN293 is a potent selective and brain permeable small-molecule inhibitor of potassium (K ) ion channel KCNK13 with an IC50s of 49 nM and 28 nM for hKCNK13 and mKCNK13 respectively It also inhibits NOD-like receptor protein 3 (NLRP3) inflammasome-mediated IL-1 production in LPS-stimulated primary neonatal murine microglia with an IC50 of 24 nM and has potential applications in Alzheimer s disease research
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