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AdipoGen CX-4945 HCl
SDP

Supplier:  AdipoGen AGCR13629M005

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Chemical. CAS 1009820-21-6 free acid. Formula C19H12ClN3O2 . HCl. MW 349.8 . 36.5. Synthetic. Orally active, potent and selective ATP-competitive inhibitor of the protein kinase CK2 IC50=1nM. Anticancer compound. Inhibits proliferation in a panel of cancer cell lines that overexpress CK2. Inhibited migration, blocks survival and induces apoptosis in cancer stem cells, glioblastomas and leukemia cells. Shown to decrease the glucose metabolism in cancer cells. Potent inhibitor of Cdc2-like kinases Clks in vitro, consequently interfering with alternative splicing. Potent ATP-competitive inhibitor of DYRK1A IC50=6.8 nM, involved in neurodegenration-associated diseases. CK2alpha deletion selectively increased M3 muscarinic receptors M3Rs-mediated insulin secretion from pancreatic islets. Promoted cAMP-induced thermogenesis in white adipocytes. CK2 inhibition ameliorates diet-induced obesity and insulin resistance in mice in vivo by promoting UCP1-dependent thermogenesis.

Catalog No. 50-256-2258


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