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Apexbio Technology LLC CX-6258 1202916-90-2 10mg
Supplier: Apexbio Technology LLC A333710
CX-6258 (CAS 1202916-90-2) is a potent selective and orally bioavailable inhibitor targeting all three Pim kinase isoforms (PIM-1 PIM-2 and PIM-3) serine/threonine kinases implicated in cell survival regulation In cellular assays CX-6258 suppressed proliferation across a diverse panel of human solid tumor and hematologic malignancy cell lines and demonstrated synergistic effects with chemotherapeutic agents In vivo CX-6258 produced dose-dependent tumor growth inhibition in MV-4-11 acute myeloid leukemia and PC3 prostate cancer xenograft models These properties make CX-6258 a valuable research tool for investigating Pim kinase biology and oncogenic mechanisms
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