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Apexbio Technology LLC CYC116 693228-63-6 200mg
Supplier: Apexbio Technology LLC A4125200
CYC116 (CAS 693228-63-6) is a small-molecule inhibitor targeting Aurora kinases A and B critical serine/threonine kinases involved in mitotic processes such as centrosome maturation spindle assembly and cytokinesis CYC116 demonstrates potent inhibition with IC50 values of 44 nM for Aurora A and 19 nM for Aurora B and Ki values of 8 nM and 9 2 nM respectively In vitro studies indicate that CYC116 disrupts mitosis induces polyploidy and triggers cell death in cancer cells Preliminary in vivo assessments reveal oral bioavailability and antitumor activity CYC116 is currently under evaluation in phase I clinical trials as an anticancer agent
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