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Medchemexpress LLC Cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-L-cysteinyl) | 862772-11-0 | 98.1% | 578.64 | 10 MG
Supplier: Medchemexpress LLC HYP230010MG
Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC) is a cyclic RGD peptide with high affinity to αvβ3, capable of disrupting cell integrin interactions. It inhibits pluripotent marker expression in embryonic stem cells (ESCs) and reduces the tumorigenic potential of mESCs in vivo. This compound is primarily used in tumor research.
- Down-regulates transcription factors Oct 4, Sox 2, and Nanog in mESCs.
- Inhibits integrin gene expression in mESC-col I (type I collagen) constructs.
- Leads to the formation of aggregates and detachment from surfaces in mESCs.
- MESC tumor formation in vivo is dependent on integrin interaction.
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