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Medchemexpress LLC Cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-L-cysteinyl) | 862772-11-0 | 98.1% | 578.64 | 25 MG
Supplier: Medchemexpress LLC 25MGHYP2300A
Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC) is a cyclic RGD peptide with high affinity to αvβ3, capable of disrupting cell integrin interactions. It inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo. This product can be used in tumor research.
- High affinity for αvβ3
- Disrupts cell integrin interactions
- Inhibits pluripotent marker expression in embryonic stem cells (ESCs)
- Inhibits tumorigenic potential of mESCs in vivo
- Useful in tumor research
- Down-regulates transcription factors Oct 4, Sox 2 and Nanog of mESCs
- Inhibits integrin gene expression in mESC-col I constructs
- Leads to formation of aggregates and detachment from surface when treated with mESC
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