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Medchemexpress LLC cyclo(RLsKDK) | 1975145-82-4 | 98.85% | 727.85 | 1 MG
SDP

Supplier:  Medchemexpress LLC HYP16761MG

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cyclo(RLsKDK) (BK-1361) is a specific inhibitor of metalloproteinase ADAM8, demonstrating an IC50 value of 182 nM. This compound holds potential applications in the treatment of inflammatory diseases and various cancers.

  • Specific inhibitor of metalloproteinase ADAM8 (IC50 182 nM).
  • Potential applications in inflammatory diseases and cancer research.
  • Promotes ADAM8 activation and CD23 shedding.
  • Increases activity of pro-ADAM8.
  • Induces ERK1/2 phosphorylation in Panc1_ctrl and Panc1_A8 cells.
  • Reduces cell invasion in a dose-dependent manner.
  • Significantly reduces tumor load and improves survival in PDAC mouse models.
  • Decreases soluble ADAM8 content, pERK1/2 activation, and PDAC metastasis.

Catalog No. 50-004-23796


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