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Medchemexpress LLC Cyclo(RLsKDK) | 1975145-82-4 | 98.9% | 727.85 | 5 MG
SDP

Supplier:  Medchemexpress LLC HYP16765MG

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cyclo(RLsKDK) (BK-1361) is a specific inhibitor of metalloproteinase ADAM8 with an IC50 value of 182 nM. It demonstrates potential applications in the treatment of inflammatory diseases and cancer.

  • Inhibits metalloproteinase ADAM8.
  • Promotes ADAM8 activation and CD23 shedding.
  • Increases activity of pro-ADAM8.
  • Promotes growth of Panc1_ctrl and Panc1_A8 cells.
  • Induces ERK1/2 phosphorylation in Panc1_ctrl and Panc1_A8 cells.
  • Significantly reduces tumor load in mice with Panc1_ctrl or Panc1_A8 cell implants.
  • Improves survival rate of pancreatic ductal adenocarcinoma (PDAC) mice.
  • Reduces soluble ADAM8 (sADAM8) content and pERK1/2 activation in PDAC mice.
  • Decreases PDAC metastasis in the liver and lungs of PDAC mice.

Catalog No. 50-004-24364


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