Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC Cyclo(RLsKDK) TFA | 99.66% | 841.88 | 5 MG
Supplier: Medchemexpress LLC HYP1676A5MG
Cyclo(RLsKDK) TFA is a specific metalloproteinase ADAM8 inhibitor (IC50 182 nM) with potential applications in inflammatory diseases and cancer. It promotes ADAM8 activation and CD23 shedding in vitro, and significantly reduces tumor load and improves survival in pancreatic ductal adenocarcinoma (PDAC) mouse models.
- Specific inhibitor of metalloproteinase ADAM8
- Applications in inflammatory diseases and cancer
- Promotes ADAM8 activation and CD23 shedding
- Increases activity of pro-ADAM8
- Promotes growth of Panc1_ctrl and Panc1_A8 cells
- Causes ERK1/2 phosphorylation
- Reduces tumor load in mouse models
- Improves survival in PDAC mice
- Reduces soluble ADAM8 (sADAM8) content
- Decreases pERK1/2 activation and PDAC metastasis
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?