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Cayman Chemical CyclogunIlhydrochlorIde 10mg
SDP

Supplier:  Cayman Chemical 1686110 MG

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The active metabolite of proguanil; formed from proguanil by CYP2C19 and CYP3A in human liver microsomes; an inhibitor of DHFR (Kis = 1.5 and 0.79 nM for the P. falciparum and P. berghei enzymes, respectively); active against ten P. falciparum field isolates (IC50s = 0.12-1,400 UG/ml); reduces parasitemia in a mouse model of P. berghei infection (ED50 = 2 mg/kg); reduces parasitemia in a rhesus monkey model of P. cynomolgi infection at 0.3 mg/kg

Catalog No. 50-296-7187


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