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Apexbio Technology LLC Cyclosporin H 83602-39-5 1mg
Supplier: Apexbio Technology LLC B59211
Cyclosporin H (CAS 83602-39-5) is a potent selective and competitive antagonist of the formyl peptide receptor (FPR) a G protein-coupled receptor involved in chemotaxis and immune cell responses to infection In human neutrophils Cyclosporin H inhibits FMLP-induced superoxide (O2-) generation with an IC50 of 0 7 M and blocks FMLP binding to cell membranes (IC50 0 7 M Ki 0 10 M) It also inhibits FMLP-stimulated GTP hydrolysis intracellular Ca2 increase O2- production and -glucuronidase release in a concentration-dependent manner In basophils Cyclosporin H competitively suppresses FMLP-induced leukotriene C4 and histamine release Additionally it promotes apoptosis in mouse bronchial eosinophils when co-administered with interleukin-5 or GM-CSF Cyclosporin H is valuable for studies investigating FPR-mediated cellular processes and inflammatory mechanisms
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