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Apexbio Technology LLC CZC24832 1159824-67-5 5mg
Supplier: Apexbio Technology LLC A33405
CZC24832 (CAS 1159824-67-5) is a selective small-molecule inhibitor of phosphoinositide 3-kinase gamma (PI3K ) a member of the class I PI3K family involved in the regulation of cellular processes such as growth differentiation survival and migration Through high-throughput chemoproteomic profiling CZC24832 was identified as a tool compound to dissect PI3K function In vitro studies demonstrate that CZC24832 specifically inhibits PI3K -mediated signaling pathways notably modulating differentiation of T helper 17 (TH17) cells and reducing interleukin-17 production In vivo the compound exhibits activity in models of inflammation indicating its utility in investigating the role of PI3K in immune-mediated and inflammatory diseases
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