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Medchemexpress LLC D-3 | 1967815-98-0 | 99.49% | 10 MG
SDP

Supplier:  Medchemexpress LLC HYP228610MG

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D-3 is a phosphorpeptide acting as an efficient and specific iPSC-eliminating agent. It prevents iPSC-induced teratoma formation and significantly reduces iPSC viability, with minimal effects on non-iPSCs such as hepatocytes and neurons.

  • Efficient and specific iPSC-eliminating agent.
  • Prevents iPSC-induced teratoma formation.
  • Induces viability loss in 201B7 cells (IC50 of 192.3 ± 57.4 μM).
  • Activates eIF2a, p38, and p44/42 MAPK, indicating cellular stress.
  • Increases apoptotic and dead cells (Annexin-V and SYTOX-positive).
  • Minimal impact on non-iPSCs (hepatocytes, neurons).
  • 400 μM for 1-2 hours induces >99% viability loss in human iPSC lines and >95% in human ESC line khES1.

Catalog No. 50-004-22554


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