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Medchemexpress LLC D(+)-Galactosamine (hydrochloride) | 1772-03-8 | 99.9% | 215.63 | 200 MG
Supplier: Medchemexpress LLC HY42682200MG
D(+)-Galactosamine hydrochloride is an established experimental toxin that primarily causes liver injury by generating free radicals and depleting UTP nucleotides. It also induces renal dysfunction, with renal failure often associated with the end-stage of liver damage. Lipopolysaccharide/D(+)-Galactosamine-induced acute liver injury is a known animal model of fulminant hepatic failure.
- Induces apoptosis and necrosis in primary cultures of rat hepatocytes.
- Induces caspase-3 activation and DNA fragmentation.
- Used to induce hepatitis models similar to viral hepatitis.
- Induces lipid peroxidation and deterioration of cell membranes.
- Can be used in rat models (Wistar) to study liver damage.
- Can be used in mouse models (C57BL/6J) for acute liver failure induction.
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