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Medchemexpress LLC D-Histidine hydrochloride hydrate | 328526-86-9 | >99.46% | 209.63 | 500 MG
Supplier: Medchemexpress LLC HYW012572A500MG
D-Histidine hydrochloride hydrate is an anti-biofilm agent with antibacterial activity, primarily targeting bacterial quorum sensing systems like the RhlI/RhlR pathway. It works by non-covalently binding to bacterial regulatory factors or copper ion complexes, selectively inhibiting bacterial biofilm formation and motility.
- Downregulates quorum sensing-related gene expression.
- Reduces the synthesis of virulence factors such, as alginate and proteases.
- Interferes with bacterial membrane stability.
- Inhibits biofilm formation and promotes the disintegration of mature biofilms.
- Enhances antibiotic sensitivity.
- Functions as an efficient catalyst for the salt-induced peptide formation (SIPF) reaction, promoting the condensation of amino acids to form dipeptides.
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