Cayman Chemical DacarbazIn 500mg

Supplier:  Cayman Chemical 21877500 MG

A DNA alkylating prodrug; converted into a methyldiazonium cation that alkylates DNA at all phases of the cell cycle and induces apoptosis; inhibits the growth of B16/F1, A-875, and SK-MEL-5 melanoma and non-cancerous WI-38 lung fibroblast and L-02 hepatocyte cell lines (IC50s = 260, 287, 380, 526, and 367 μM, respectively); toxicity to 518A2 and SK-MEL-28 melanoma cell lines increases in a time-dependent manner (IC50s = 121 and >400, respectively, at 1 hour and 2.5 and 50 μM, respectively, at 96 hours); decreases tumor volume by 59.1% in a B16/F1 murine melanoma model in mice (70 mg/kg, once every 2 days)

Catalog No. 50-298-6094