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Apexbio Technology LLC Daclatasvir (BMS-790052) 1009119-64-5; 1214735-16-6 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A56185.1
Daclatasvir previously identified as BMS-790052 is a selective inhibitor targeting hepatitis C virus (HCV) non-structural protein 5A (NS5A) a 447 amino-acid zinc-associated phosphoprotein involved in viral replication and assembly processes Although NS5A lacks intrinsic enzymatic activity daclatasvir may exert antiviral effects through perturbation of NS5A structural conformations possibly disrupting protein dimerization In replicon assays assessing multiple HCV genotypes (1a and 1b) as well as NS5A coding region chimeras daclatasvir inhibited viral RNA replication at picomolar concentrations Due to its activity profile and defined mechanism daclatasvir serves as a research tool to elucidate NS5A biology and as a candidate agent in experimental therapeutic regimens targeting chronic HCV infection
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