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Apexbio Technology LLC Dantrolene, sodium salt 14663-23-1 100mg
Supplier: Apexbio Technology LLC B6329100
Dantrolene sodium salt (CAS 14663-23-1) is a small-molecule antagonist of the ryanodine receptor (RyR) exhibiting an IC50 of 5 9 0 3 nM for RyR2 RyRs located on the endoplasmic and sarcoplasmic reticulum regulate intracellular Ca sup 2 /sup release and their dysregulation contributes to conditions such as ischemia neurodegenerative diseases and trauma In mouse cardiomyocytes dantrolene reduced Ca sup 2 /sup wave frequency and amplitude in the presence of calmodulin indicating calmodulin dependence for RyR inhibition In in vivo models of pancreatitis dantrolene decreased pancreatic trypsin activity and serum amylase supporting its use in research on calcium-mediated cellular injury
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