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Medchemexpress LLC DAPT | 208255-80-5 | 100.0% | 200 MG
Supplier: Medchemexpress LLC HY13027200MG
DAPT is a potent and orally active γ-secretase inhibitor. It inhibits the activation of Notch 1 signaling and induces cell differentiation, autophagy, and apoptosis. This compound exhibits neuroprotection activity and holds potential for the treatment of autoimmune and lymphoproliferative diseases, degenerative diseases, and various cancers.
- Inhibits γ-secretase with IC50s of 115 nM for total amyloid-β (Aβ) and 200 nM for Aβ42.
- Inhibits activation of Notch 1 signaling.
- Induces cell differentiation, autophagy, and apoptosis.
- Exhibits neuroprotection activity, particularly in cerebral ischemia models.
- Potential therapeutic agent for autoimmune and lymphoproliferative diseases.
- Potential therapeutic agent for degenerative diseases and cancers.
- Useful in research for Alzheimer's disease, cell differentiation, autophagy, and apoptosis.
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