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Enzo Life Sciences DAPT (25mg). CAS: 208255-80-5
SDP

Supplier:  Enzo Life Sciences ALX270416M025

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Cell permeable inhibitor of γ-secretase (IC50=115nM for total β-amyloid, IC50=200nM for β-amyloid 1-42). It reduces Aβ levels in vivo in plasma and cerebrospinal fluid in young and aged Tg2576 mice. It blocks the proteolytic processing of neurotrophin receptor alike death domain protein (NRADD)Does not inhibit presenilinase. Antagonizes Notch signaling through inhibition of Notch processing. DAPT treatment can influence hematopoietic cell fate decisions and enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independent of sonic hedgehog (shh) signaling. Alternative name: N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine tert-butyl ester, gamma-Secretase inhibitor IX. Purity: ≥98% (HPLC). Solubility: Soluble in 100% ethanol, DMSO (20mg/ml) or dichloromethane. Long Term Storage: -20°C.

Catalog No. 50-200-8542


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