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Cayman Chemical DarIfenacInhydrobromIde 10mg
Supplier: Cayman Chemical 1442410 MG
A muscarinic M3 receptor antagonist (Ki = 0.76 nM); selective for M3 over M1, M2, M4, and M5 mAChRs (Kis = 7.08, 44.67, 45.71, and 9.33 nM, respectively); selectively inhibits contractions in isolated guinea pig ileum, bladder, and trachea (pA2s = 9.44, 8.66, and 8.7, respectively) over isolated rabbit vas deferens and isolated guinea pig atria (pA2s = 7.9 and 7.48, respectively); inhibits micturition pressure (ED50 = 0.089 mg/kg, i.v.), as well as micturition interval and volume in rats
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