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Medchemexpress LLC Darunavir Ethanolate | 635728-49-3 | 99.9% | 593.73 | 200 MG
Supplier: Medchemexpress LLC HY17041200MG
Darunavir ethanolate (TMC114 Ethanolate) is a potent HIV protease inhibitor used to treat and prevent HIV/AIDS. It has a Ki of 1 nM for wild type HIV-1 protease.
- Broad-spectrum potent inhibitor active against HIV-1 clinical isolates with minimal cytotoxicity.
- Forms hydrogen bonds with the conserved main-chain atoms of Asp29 and Asp30 of the protease, critical for potency against HIV isolates resistant to multiple protease inhibitors.
- Shows greater potency than other inhibitors in MT-2 cells.
- Primarily metabolized by hepatic cytochrome P450 (CYP) enzymes, mainly CYP3A.
- Is effective against wild-type and PI-resistant HIV.
- Has an oral bioavailability of 37%, which increases to 82% when combined with ritonavir.
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