Apexbio Technology LLC Dasatinib Monohydrate 863127-77-9 100mg

Supplier:  Apexbio Technology LLC B5954100

Dasatinib Monohydrate (CAS 863127-77-9) is a small molecule inhibitor primarily targeting Bcr-Abl and Src family tyrosine kinases with IC50 values of 3 0 nM and 0 55 nM respectively It acts as an ATP-competitive inhibitor and demonstrates broad-spectrum antiproliferative activity in both hematological and solid tumor cell models Dasatinib is effective in suppressing wild-type and the majority of imatinib-resistant BCR-ABL kinase variants In murine studies oral administration of dasatinib reduced disease progression and bioluminescence levels in BCR-ABL-driven leukemia models Dasatinib is widely employed in research on kinase signaling and drug resistance mechanisms in Ph-positive leukemias

Catalog No. 50-000-95327