Medchemexpress LLC DBCO-mPEG (MW 5kDa) | 99.1% | 100 MG

Supplier:  Medchemexpress LLC HY140319100MG

DBCO-mPEG (MW 5kDa) is a PEG-based PROTAC linker that plays a crucial role in the synthesis of PROTACs. This compound acts as a click chemistry reagent, incorporating a DBCO group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing azide groups. PROTACs themselves are engineered with two distinct ligands connected by a linker: one ligand targets an E3 ubiquitin ligase, and the other targets a specific protein, allowing for the selective degradation of target proteins through the intracellular ubiquitin-proteasome system.

• PEG-based PROTAC linker
• Utilized in PROTAC synthesis
• Functions as a click chemistry reagent
• Contains a DBCO group for SPAAC with azide-containing molecules
• Enables selective degradation of target proteins

Catalog No. 50-003-57248